We thank Professor Siriwardena and colleagues for their valuable comments on our manuscript.
1It seems like we share the view that arranging a randomized controlled trial for patients with colorectal cancer and synchronous liver metastases is hard, if not unfeasible. We are happy to see that the authors highlight our algorithmic approach to patient selection in devising a treatment plan. Finally, we agree with Professor Siriwardena and colleagues, that treatment decisions in the future will be more influenced by an in-depth knowledge of the biology of the primary cancer, and perhaps also the biology of the metastases. Recent developments in spatial transcriptomics point towards a more precision based medicine.
- Fruhling P.
- Stromberg C.
- Isaksson B.
- Urdzik J.
A comparison of the simultaneous, liver-first, and colorectal-first strategies for surgical treatment of synchronous colorectal liver metastases at two major liver-surgery institutions in Sweden.
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- A comparison of the simultaneous, liver-first, and colorectal-first strategies for surgical treatment of synchronous colorectal liver metastases at two major liver-surgery institutions in Sweden.HPB. 2022;
Published online: March 18, 2023
Accepted: March 10, 2023
Received: March 3, 2023
Publication stageIn Press Uncorrected Proof
© 2023 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.