Abstract
Background
Hepatic venous pressure gradient (HVPG) is the criterion for assessing sinusoidal
portal hypertension. Using HVPG to assess the degree of liver fibrosis by transjugular
liver biopsy (TJLB) is still being explored, as no data has been shown that portal
hypertension may already be present in patients with advanced hepatic fibrosis (Scheuer
stage ≥ S3). The objective of this study was to observe whether portal hypertension
exists before progressing to cirrhosis (Scheuer stage = S4).
Methods
Fifty patients who underwent TJLB and HVPG were enrolled. The correlation between
Scheuer stage and HVPG was analyzed using the Pearson correlation coefficient, and
the ROC curve predicted the diagnostic value of HVPG in patients with hepatic fibrosis.
Results
The Scheuer stage and HVPG significantly correlated (r = 0.654, p < 0.001). The AUC
of HVPG in predicting advanced liver fibrosis was 0.896, and of cirrhosis was 0.810.
There were 45 patients with portal hypertension (HVPG> 5 mmHg), 12 with S3, 29 with
S4; There were 42 patients with CSPH (HVPG≥ 10 mmHg), 11 with S3, and 29 with S4.
Conclusion
HVPG is valuable in evaluating the Scheuer stage of liver fibrosis in patients with
TJLB. Portal hypertension might already exist before the progression to cirrhosis
in some patients.
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Article info
Publication history
Published online: February 13, 2023
Accepted:
February 9,
2023
Received:
August 27,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.
