Abstract
Background
The diagnosis of postoperative or post-pancreatectomy acute pancreatitis (PPAP) is
controversial. In 2021, the International Study Group of Pancreatic Surgery (ISGPS) published the first unifying definition and grading system for PPAP. This
study sought to validate recent consensus criteria, using a cohort of patients undergoing
pancreaticoduodenectomy (PD) in a high-volume pancreaticobiliary specialty unit.
Methods
All consecutive patients undergoing PD at a tertiary referral centre between January
2016 and December 2021 were retrospectively reviewed. Patients with serum amylase
recorded within 48h from surgery were included for analysis. Postoperative data were
extracted and evaluated against the ISGPS criteria, including the presence of postoperative
hyperamylasaemia, radiologic features consistent with acute pancreatitis, and clinical
deterioration.
Results
A total of 82 patients were evaluated. The overall incidence of PPAP was 32% (26/82)
in this cohort, of which 3/26 demonstrated postoperative hyperamylasaemia and 23/26
had clinically relevant PPAP (Grade B or C) when correlated radiologic and clinical
criteria.
Conclusions
This study is among the first to apply the recently published consensus criteria for
PPAP diagnosis and grading to clinical data. While the results support their utility
in establishing PPAP as a distinct post-pancreatectomy complication, there remains
a need for future large-scale validation studies.
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Article info
Publication history
Published online: February 02, 2023
Accepted:
January 30,
2023
Received:
September 12,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.
